![]() ![]() ![]() ![]() One hypothesis is that they spread hematogenously following introduction into the blood during tooth brushing, dental cleanings, or subsequent to oral diseases such as periodontitis. All HACEK organisms are commensals of the human oropharynx but how they travel to distal sites to cause disease is not fully established. The HACEK group is not based on taxonomic relationships but on the organisms’ propensity to cause endocarditis. HACEK Organisms are Associated with Infective Endocarditis The acronym stands for H aemophilus, Aggregatibacter, C ardiobacterium, E ikenella, and K ingella: all HACEK members are fastidious Gram-negative bacteria associated with infective endocarditis. The acronym “HACEK” is common in clinical microbiology, although its pronunciation may be somewhat controversial (hay-sek or hah-sek?). ![]()
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